This is a new game that commuters are participating in: Roadside Math.
Looks like a way to beat the boredom.
An example:
Give Me Liberty
Give me Liberty, or give me a square root! How appropriate that this winning mathematically significant road sign with Liberty is from Pennsylvania. This is another sign from David Slauenwhite.

Two number signs almost always have to use functions that only require one number and this is no exception. It’s easy to try to make this 42 = 16 but that is not a valid solution, there is no 2 on this sign anywhere for the power. However, the opposite using the square root is completely within the rules.
SqRt(16) = 4
This sign is found in Pennsylvania on PA 414 West in Canton, immediately west of PA 14. The GPS coordinates for this sign are approximately N41 39 10.7 W76 51 09.6.
I walk to work so I can’t play and there are no road signs on the river I kayak.
MarkB